Recombinant Human RANKL (TNFSF11) (E. coli)

Cat. No.
Z102265
Unit
Price
$246.00
Cat. No. Z102265
Name Recombinant Human RANKL (TNFSF11) (E. coli)
Description Human RANKL is a member of the tumour necrosis factor superfamily. It primarily affects the immune system by controlling bone regeneration and remodeling. It functions in osteoclast differentiation and activation. It also is expressed by T helper cells as a factor in dendritic cell maturation and survival. It is expressed after T-cell activation. It also appears to have a role in the regulation of apoptosis through activation of the antiapoptotic kinase AKT/PKB. It is not only expressed by immune cells, but also on a number of other cells in the lung, thymus, skeletal muscle and many others. It can be expressed as a trimeric transmembrane protein, a secreted form or a truncated ectodomain. Human RANKL shares 85% sequence similarity with mouse RANKL.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family TNF Super-family
Aliases soluble Receptor Activator of NFkB Ligand, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)
Gene Symbol TNFSF11
Gene ID 8600
Accession Number O14788
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 20 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 µm filtered solution in PBS
Function coming soon
Reconstitution A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z102265
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