Recombinant Human RANTES (CCL5) (E. coli)

Cat. No.
Cat. No. Z100785
Name Recombinant Human RANTES (CCL5) (E. coli)

RANTES belongs to the family of chemotactic cytokines known as chemokines and is expressed by an early response gene. The synthesis of RANTES is induced by TNF-alpha and IL-1-alpha. RANTES is chemotactic for T cells, human eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. RANTES also activates eosinophils to release eosinophilic cationic protein while being a potent activator of oxidative metabolism specific for eosinophils. RANTES increases the adherence of monocytes to endothelial cells and selectively supports the migration of monocytes and T lymphocytes expressing the cell surface markers CD4 and UCHL1.

Organism Human (H. sapiens)
Unit quantity 20 µg
Family Chemokine-beta Family (CC)

Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta, C-C motif chemokine 5, EoCP, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, TCP228, T-cell-specific protein RANTES, D17S136E, SCYA5

Gene Symbol CCL5
Gene ID 6352
Accession Number P13501
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 9 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method

>95% as determined by SDS-PAGE

Formulation Lyophilized from a 0.2µm filtered solution in 50mM NaAc, pH 5.0, 100mM NaCl.
Function Determined by its ability to chemoattract human blood monocytes using a concentration range of 1-10 ng/mL.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z100785
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