Recombinant Human TGF Beta-3 (TGFB3) (E. coli)

Cat. No.
Cat. No. Z102515
Name Recombinant Human TGF Beta-3 (TGFB3) (E. coli)

Transforming Growth Factor Beta-3 is a disulfide-linked homodimeric, non-glycosylated, protein that is one of the isoforms of the highly pleiotropic cytokines that are secreted by all cell types. TGF Beta-1, TGF Beta-2, and TGF Beta-3 use the same receptor and act as cellular switches that regulate cell growth, proliferation, differentiation, motility, extracellular matrix synthesis, and immune function regulation. Defects of this gene can cause arrhythmogenic right ventricular dysplasia 1 and rienhoff syndrome. TGFB3 first interacts with the accessory receptor betaglycan (TGF Beta-R3) and a type II serine/threonine kinase receptor (TGF Beta-R2). The receptor then activates a type I serine/threonine kinase receptor such as ALK-1 or TGF Beta-R1 (ALK-5) through phosphorylation, and the activated type I receptor activates Smad proteins to regulate transcription.

Organism Human (H. sapiens)
Unit quantity 10 µg
Family TGF-beta Super-family
Aliases Transforming growth factor beta-3
Gene Symbol TGFB3
Gene ID 7043
Accession Number P10600
Source E. coli
Species Human (H. sapiens)
Appearance Liquid
Molecular Weight 13 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method

>95% as determined by SDS-PAGE

Formulation The filter sterilized solution contains 20% Ethanol and 0.06% Acetic acid.
Function The ED50 is 0.01-0.04 ng/mL as determined by its ability to inhibit IL-4 dependent proliferation of HT-2 mouse cells
Storage This cytokine can be stored in working aliquots at 2° - 8°C for two weeks. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z102515
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