Recombinant Human THBS1

Cat. No.
Z101395
Unit
10 µg
Price
$246.00
Cat. No. Z101395
Name Recombinant Human THBS1
Description TSP is an adhesive protein that can bind to many different cell types, including hematopoietic progenitor cells. It possesses a number of functional domains that serve as receptor recognizing regions. The amino-terminal heparin-binding domain interacts with heparin, other glycosaminoglycans and glycolipids and likely recognizes specific cell surface proteoglycans. The central disulfide cross-linked region is responsible for high affinity binding to one of the CD antigens, CD36 . TSP has been demonstrated to bind to integrin-alpha-V , integrin-beta-3 and integrin-alpha-2b, integrin-beta-3. The carboxy-terminal region of TSP also contains at least one binding epitope for a cell receptor. TSP can interact with fibrinogen and fibronectin. TSP appears to be involved intimately in the regulation of cellular proliferation. It is expressed as an early response gene following treatment of cells with various mitogens and cytokines. It modulates the progression of cells through the cell cycle. It augments the proliferative response to EGF. TSP inhibits endothelial cell chemotactic response to bFGF and reduces their proliferative response to serum and bFGF.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family Other Growth Factors/Cytokines
Aliases TSP, TSP1, THBS1
Recombinant Human Thrombospondin-1 (THBS1)
Gene Symbol THBS1
Accession Number P07996
Source Insect cells
Species Human (H. sapiens)
Appearance Liquid
Molecular Weight 140 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Recombinant Thrombospondin-1 is presented as liquid formulation of 0.3 M NaCl, 0.02 M NaH2PO4 pH 6.0 .
Function Not available at this time
Storage This cytokine should be stored in working aliquots at 2° - 8°C for one year. Avoid freezing.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101395
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