Recombinant Human THPO

Cat. No.
Z101515
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Cat. No. Z101515
Name Recombinant Human THPO
Description Thrombopoietin, known also as TSF (thrombopoiesis stimulating factor), for mediator substances that function as natural stimulators of megakaryocytopoiesis and thus, promote the differentiation of platelets. Thrombopoietin stimulates an increase in the sizes and numbers of megakaryocytes. It also increases the number of small acetyl-cholinesterase positive cells that are early precursor cells of the megakaryocytic lineage. Thrombopoietin is a protein of 332 amino acids that shows significant homology with Epo (erythropoietin) in its N-terminal domain. A comparison of human and porcine Thrombopoietin sequences shows 83 % identity between the erythropoietin-like domains but only 67 % between the C- terminal domains.
Organism Human (H. sapiens)
Unit quantity 10 µg
Family HDGF/S-100/EPO(TPO) Families
Aliases

C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand
Recombinant Human Thrombopoietin (THPO)

Gene Symbol THPO
Gene ID 7066
Accession Number P40225
Source HEK293 cells
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 35 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity Greater than 95% as observed by SDS-PAGE.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.0)
Function The ED50 as determined by the dose-dependent proliferation of Mo7e cells was found to be in the range of 1-2 ng/mL
Reconstitution

It is recommended to reconstitute the lyophilized Thrombopoietin in sterile PBS containing 0.1% endotoxin-free recombinant HSA.

Storage Lyophilized Thrombopoietin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TPO should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z101515
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