Recombinant Human TNFSF15 (E. coli)
Cat. No.
Z102335
Unit
Price
$92.00
| Cat. No. | Z102335 |
| Name | Recombinant Human TNFSF15 (E. coli) |
| Description | TNFSF15 is a type II transmembrane protein which is predominantly expressed in endothelial cells. It has a single transmembrane domain, a small cytoplasmic domain and an extracellular C-terminus. Its expression is stimulated by TNFA and IL1A. TNFSF15 acts as the ligand for the receptor protein TNFRSF25 which is primarily found in activated T cells. It also has an affinity to the decoy receptor protein TNFRSF6B. Binding of this cytokine to its receptor can activate the transcription factor NF-Kappa-B and MAP Kinases. It has been found that TNFSF15 can also induce apoptosis by acting as an autocrine factor and inhibit endothelial cell proliferation. Recombinant Human TNFSF15 herein refers to the secreted form of the protein. |
| Organism | Human (H. sapiens) |
| Unit quantity | 50 µg |
| Family | TNF Super-family |
| Tag | Tag Free |
| Gene Symbol | TNFSF15 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Formulation | Lyophilized from a 0.2 micron filtered solution in Tris and salt |
| Function | The ED(50) was determined by the dose-dependent proliferation of Jurkat cells and was found to be <0.5ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in sterile distilled water to a concentration not less than 0.1 mg/mL is recommended. This solution can then be diluted into other buffers. |
| Shipping Conditions | This lyophilized protein is shipped at ambient temperature. Cold packs may be used if transit temperatures are elevated. The product remains stable during normal shipping conditions. |
| Storage | Upon receipt, store lyophilized protein at –70°C for long-term storage. Short-term storage at –20°C is acceptable if necessary. Once reconstituted, store at 2–8°C for up to 1 month, or at –20°C for up to 6 months. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
| Material Citation | If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z102335 |
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| What is the shelf life and storage condition of this product? | |
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The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
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