Recombinant Human TWEAK Receptor (TNFRSF12A) (E. coli)

Cat. No.
Z102525
Unit
Price
$126.00
Cat. No. Z102525
Name Recombinant Human TWEAK Receptor (TNFRSF12A) (E. coli)
Description Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) is the receptor for TNFSD12/TWEAK and is the smallest member of the TNF receptor superfamily. It is composed of a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic “death” domain, which can activate a cell’s apoptotic mechanisms. It also promotes endothelial cell proliferation and angiogenesis, and modulates cellular adhesion to matrix proteins. TNFRSF12A expression can be found in the spleen, thymus, small intestine, and colon, and can be activated by membrane-anchored or soluble versions of TWEAK.
Organism Human (H. sapiens)
Unit quantity 25 µg
Family TNF Super-family
Aliases Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, CD-antigen: CD266
Gene Symbol TNFRSF12A
Gene ID 51330
Accession Number Q9NP84
Source E. coli
Species Human (H. sapiens)
Appearance Lyophilized Powder
Molecular Weight 5.6 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Formulation Lyophilized from a 0.2 µm filtered solution in PBS
Function The ED(50) was determined by the dose-dependent proliferation of human umbilical vein endothelial cells and was found to be <0.2ng/mL.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z102525
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