Recombinant Mouse IL18BP

Cat. No.

Z200429

Unit

Price

$3,900.00

Cat. No.	Z200429
Name	Recombinant Mouse IL18BP
Description	IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular isoforms. IL-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that resembles the extracellular domains of Ig-like receptors but has no transmembrane form. Because IL-18 is one of the early signals leading to IFN-gamma production by Th1 cells, blocking IL-18 activity by IL-18BP may be involved in down-modulation of the early phases of immune responses.
Organism	Mouse (M. musculus)
Unit quantity	1.0 mg
Family	IL-1 Family
Tag	Tag Free
Aliases	IL-18BP, Igifbp, MC54L
Gene Symbol	IL18BP
Gene ID	16068
Accession Number	Q9Z0M9
Source	E. coli
Species	Mouse (M. musculus)
Appearance	Lyophilized Powder
Molecular Weight	approximately 45 kDa
Endotoxin Level	<1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity	>95% as determined by SDS-PAGE
Formulation	Recombinant IL-18BP is supplied as an 0.2 μm filtered PBS solution.
Function	The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA.
Reconstitution	A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Shipping Conditions	This lyophilized protein is shipped at ambient temperature. Cold packs may be used if transit temperatures are elevated. The product remains stable during normal shipping conditions.
Storage	Upon receipt, store lyophilized protein at –70°C for long-term storage. Short-term storage at –20°C is acceptable if necessary. Once reconstituted, store at 2–8°C for up to 1 month, or at –20°C for up to 6 months. Avoid repeated freeze/thaw cycles.
Usage	For research use only. Not for diagnostic or therapeutic use.
Material Citation	If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z200429

Print/Download Datasheet

Search CoA here

MSDS

Growth Factors, Cytokines & Kinases MSDS

Other

How do I choose the right growth factor for my experiment?

Cell type: Different cells respond to different growth factors. Choose a growth factor that promotes the growth or differentiation of your target cell type.
Desired outcome: Whether you are studying proliferation, differentiation, or survival, different growth factors will promote different cellular behaviors.
Concentration and formulation: Different experiments may require varying concentrations of growth factors.

Check out Role of Growth Factors in Cell Differentiation.

	What is the shelf life and storage condition of this product?
	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.