Recombinant Mouse IL18BP (E. coli)

Cat. No.
Z200429
Unit
1.0 mg
Price
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Cat. No. Z200429
Name Recombinant Mouse IL18BP (E. coli)
Description IL-18BP is a secreted protein that binds IL-18 with high affinity and prevents its interaction with the IL-18R. Different isoforms of IL-18BP have been demonstrated, four in human and two in the murine system, and biological activity is limited to particular isoforms. IL-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that resembles the extracellular domains of Ig-like receptors but has no transmembrane form. Because IL-18 is one of the early signals leading to IFN-gamma production by Th1 cells, blocking IL-18 activity by IL-18BP may be involved in down-modulation of the early phases of immune responses.
Organism Mouse (M. musculus)
Unit quantity 1.0 mg
Family IL-1 Family
Aliases IL-18BP, Interferon gamma-inducing factor-binding protein
Recombinant Mouse Interleukin-18 Binding Protein (IL18BP)
Gene Symbol IL18BP
Gene ID 16068
Accession Number Q9Z0M9
Source E. coli
Species Mouse (M. musculus)
Appearance Lyophilized Powder
Molecular Weight 19 kDa
Endotoxin Level <1.0 EU/µg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Formulation Recombinant IL-18BP is supplied as an 0.2 μm filtered PBS solution.
Function The activity of recombinant Interleukin-18 Binding Protein was determined by the ability to bind IL-18 in functional ELISA.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.
Material Citation If use of this material results in a scientific publication, please cite the material in the following manner: Applied Biological Materials Inc, Cat. No. Z200429
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